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Drug Resistance

 Shigella sonnei acquires drug resistance via horizontal transfer of conjugative R plasmids

Published in TB and Outbreaks Week, September 5th, 2006

Shigella sonnei acquires antimicrobial resistance via horizontal transfer of conjugative R plasmids.

According to a recent report from South Korea, "The antimicrobial resistance of 122 Shigella sonnei isolates obtained in Korea during the period 1991-2000 was characterized. These isolates were highly resistant to traditional antibiotics such as trimethoprim (100%), streptomycin (1100%), sulfamethoxazole (94%), tetracycline (93%) and naliclixic acid (90%)."

"All S. sonnei isolates carried Tn 7 in their chromosomes. The 8.4kb nontransferable resistance plasmid carrying tetA, strA-strB and sul1 was found in 93% of the S....

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