Mycobacterial Pathogenesis
Mycobacterium paratuberculosis virulence determinants identified
Published in TB and Outbreaks Week, September 5th, 2006
According to recent research published in the journal Infection and Immunity, "Johne's disease, caused by Mycobacterium paratuberculosis infection, is a worldwide problem for the dairy industry and has a possible involvement in Crohn's disease in humans.
"To identify virulence determinants of this economically important pathogen, a library of 5,060 transposon mutants was constructed using Tn5367 insertion mutagenesis, followed by large-scale sequencing to identify disrupted genes."
"In this report," said the authors, "1,150 mutants...
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