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Crohn Disease
MAP/self-mimics as targets of cross-reactive antibody responses in Crohn disease
September 19th, 2006
Mycobacterium avium paratuberculosis/self-mimics as targets of cross-reactive antibody responses in Crohn's disease. According to recent research from England, "Most Crohn's disease (CD) patients show seroreactivity against Mycobacterium avium paratuberculosis (MAP), suggesting a pathogenic role for this organism. Our aim was to seek amino acid similarities between MAP and intestinal proteins that, through molecular mimicry, could serve as targets for cross-reactive immunity in CD." "Fifty-three peptides comprising 23 sets of MAP/human intestinal peptidyl mimics chosen for maximal homology were constructed and tested for immunologic...
Source: TB & Outbreaks Week (2006-09-19)
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