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Tuberculosis Predisposition
Autosomal dominant major gene confers pulmonary tuberculosis predisposition in adults
September 19th, 2006
An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults. "The molecular basis of genetic predisposition to pulmonary tuberculosis in adults remains largely elusive. Few candidate genes have consistently been implicated in tuberculosis susceptibility, and no conclusive linkage was found in two previous genome-wide screens. "We report here a genome-wide linkage study in a total sample of 96 Moroccan multiplex families, including 227 siblings with microbiologically and radiologically proven pulmonary tuberculosis," wrote scientists in France. According to J.E. Baghdadi and colleagues at the...
Source: TB & Outbreaks Week (2006-09-19)
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