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Mycobacterium Tuberculosis Pathogenesis
IL-12p40 required for dendritic cell migration and T cell priming after tuberculosis infection
September 19th, 2006
Interleukin-12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. According to recently published research from the United States, "Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. "We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40." "This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate...
Source: TB & Outbreaks Week (2006-09-19)
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