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Tuberculosis Diagnostics

Serial testing with tuberculosis interferon-gamma assay shows promise

Published in TB and Outbreaks Week, October 10th, 2006

Serial testing with the tuberculosis interferon-gamma assay shows promise.

According to recent research from Canada, "Although interferon-gamma (IFN-gamma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing performance is unknown." TST "and IFN-gamma conversions and reversions" were compared "in healthcare workers.

"We prospectively followed-up 216 medical and nursing students in India who underwent baseline and repeat testing (after 18 mo) with TST and QuantiFERON-TB Gold In-Tube (QFT). TST conversions were defined as reactions greater than or equal to 10 mm, with increments of 6 or 10 mm over baseline."

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