Antituberculosis Drug Development
Front-line antitubercular drugs synergistic with ethylene diamine SQ109
Published in TB and Outbreaks Week, October 24th, 2006
According to a recently published report from the United States, "The purpose of this study was to determine interactions of SQ109, a new asymmetric diamine tuberculosis (TB) drug candidate, with existing antitubercular drugs in vitro and assess its potential to improve combination drug activities against Mycobacterium tuberculosis.
"Two-drug combinations at various concentrations below their MiCs were tested for growth inhibition of M. tuberculosis using the BACTEC 460 system in vitro. Drug interactions were evaluated based on the quotient...
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