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Malaria Diagnostics

Malaria HHRP2 sequence variations account for performance variations of rapid diagnostic tests

Published in TB and Outbreaks Week, November 7th, 2006

Plasmodium falciparum histidine-rich protein 2 sequence variations account for performance variations of rapid diagnostic tests.

According to recent research from Australia, "The ability to accurately diagnose malaria infections, particularly in settings where laboratory facilities are not well developed, is of key importance in the control of this disease. Rapid diagnostic tests (RDTs) offer great potential to address this need.

"Reports of significant variation in the field performance of RDTs based on the detection of Plasmodium falciparum histidine-rich protein 2 (HRP2) (PfHRP2) and of significant sequence polymorphism in PfHRP2 led...

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