Legionnaire Disease
Reports outline legionnaire disease study findings from Northwestern University, Department of Microbiology
Published in TB and Outbreaks Week, November 7th, 2006
New investigation results, "Legionella pneumophila Mip, a surface-exposed peptidylproline cis-trans-isomerase, promotes the presence of phospholipase C-like activity in culture supernatants," are detailed in a study published in Infection and Immunity. "The type II secretion system of Legionella pneumophila promotes pathogenesis. Among the Legionella type II-dependent exoenzymes is a p-nitrophenol phosphorylcholine (p-NPPC) hydrolase whose activity is only partially explained by the PlcA phospholipase C," researchers in the United States report.
"In a screen to identify other factors that promote secreted hydrolase activity, we isolated a mip mutant. L....
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