Tuberculosis
Studies from AstraZeneca have provided new data on tuberculosis
Published in TB and Outbreaks Week, January 9th, 2007
Investigators publish new data in the report "High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog. RNA polymerase (RNAP) is a well-validated target for the development of antibacterial and antituberculosis agents. Because the purification of large quantities of native RNA polymerase from pathogenic mycobacteria is hazardous and cumbersome, the primary screening was carried out using Escherichia coli RNAP," scientists in Bangalore, India report.
"The authors have developed a high-throughput screening (HTS) assay to screen for novel inhibitors of RNAP. In this assay, a fluorescent analog of UTP, gamma-amino naphthalene sulfonic...
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