Tuberculosis
Findings from University of Nottingham, Center for Biomolecular Sciences broaden understanding of tuberculosis
Published in TB and Outbreaks Week, January 16th, 2007
New research, "Structure of Mycobacterium tuberculosisthioredoxin C," is the subject of a report. "Mycobacterium tuberculosis is a facultative intracellular parasite of alveolar macrophages. M. tuberculosis is able to propagate in harsh environments within cells such as phagocytes, despite being exposed to reactive oxygen and nitrogen intermediates. The thioredoxin redox system is conserved across the phyla and has a well characterized role in resisting oxidative stress and influencing gene expression within prokaryotic and eukaryotic cells. M. tuberculosis thioredoxin (MtbTrx) has similar functions in redox homeostasis and it has recently been shown that alkyl...
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