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Tuberculosis Therapy

Scientists at College of Medicine target tuberculosis therapy

Published in TB and Outbreaks Week, March 13th, 2007

Data detailed in "The chemokine receptor CXCR3 attenuates the control of chronic Mycobacterium tuberculosis infection in BALB/c mice" have been presented. According to a study from the United States, "The chemokine receptor CXCR3 plays a significant role in regulating the migration of Th1 cells. Given the importance of Th1 immunity in the control of tuberculous infection, the results of the present study demonstrating that CXCR3-deficient BALB/c mice are more resistant to Mycobacterium tuberculosis, compared with wild-type mice, is surprising."

"This enhanced resistance manifests in the chronic but not the acute phase of infection. Remarkable differences in the...

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