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Tuberculosis Cell Biology

Scientists at Trinity College describe research in tuberculosis cell biology

Published in TB and Outbreaks Week, April 17th, 2007

Researchers detail in "A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection," new data in tuberculosis. "Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation," researchers in Dublin, Ireland report.

"The intracellular pathways of apoptosis that elaborate this macrophage response are not well understood. To address this issue, we investigated the contribution of various apoptosis pathways to M. tuberculosis-induced macrophage cell death....

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