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Tuberculosis Vaccines

New tuberculosis vaccines study findings have been reported by scientists at Trudeau Institute

Published in TB and Outbreaks Week, May 8th, 2007

A report, "IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge," is newly published data in Nature Immunology. According to a study from the United States, "Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection."

"Interleukin 23 (IL-23) was essential for the accelerated response, for early cessation of bacterial growth and for establishment of an IL-17-producing CD4(+) T cell...

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