Tuberculosis
Study findings from University of Barcelona provide new insights into tuberculosis
Published in TB and Outbreaks Week, July 3rd, 2007
Research findings, "Dynamical regulation of ligand migration by a gate-opening molecular switch in truncated hemoglobin-N from Mycobacterium tuberculosis," are discussed in a new report. "Truncated hemoglobin-N is believed to constitute a defense mechanism of Mycobacterium tuberculosis against NO produced by macrophages, which is converted to the harmless nitrate anion. This process is catalyzed very efficiently, as the enzyme activity is limited by ligand diffusion," scientists in Barcelona, Spain report.
"By using extended molecular dynamics simulations we explore the mechanism that regulates ligand diffusion and, particularly, the role played by residues that...
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