Tuberculosis

Research from Heidelberg University, Biochemistry Center in the area of tuberculosis published

Published in TB and Outbreaks Week, July 10th, 2007

Research findings, "The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid," are discussed in a new report. "The universal secondary messenger cAMP is produced by adenylyl cyclases (ACs). Most bacterial and all eukaryotic ACs belong to class III of six divergent classes," scientists in Heidelberg, Germany report.

"A class III characteristic is formation of the catalytic pocket at a dimer interface and the presence of additional regulatory domains. Mycobacterium tuberculosis possesses 15 class III ACs, including Rv1264, which is activated at acidic pH due to pH-dependent structural transitions of...

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Source: TB and Outbreaks Week (2007-07-10)

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