Legionnaire Disease

Findings from Northwestern University, Department of Microbiology-Immunology in legionnaire disease reported

Published in TB and Outbreaks Week, July 17th, 2007

Data detailed in "Iron acquisition by Legionella pneumophila" have been presented. According to a study from the United States, "For nearly 20 years, it was believed that Legionella pneumophila does not produce siderophores. Yet, we have now determined that L. pneumophila secretes a siderophore (legiobactin) that is detectable by the CAS assay."

"We have optimized conditions for legiobactin expression, shown its biological activity, and found genes (lbtAB) involved in its production and secretion. LbtA is homologous with siderophore synthetases from E. coli (aerobactin), Sinorhizobium (rhizobactin), and Bordetella (alcaligin), while LbtB is a member...

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Source: TB and Outbreaks Week (2007-07-17)

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