Tuberculosis Immunology
Research on tuberculosis immunology published by scientists at Bose Institute, Department of Chemistry
Published in TB and Outbreaks Week, August 14th, 2007
New investigation results, "Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages," are detailed in a study published in Nature Immunology. According to recent research from Kolkata, India, "Expression of early secreted antigenic target protein 6 (ESAT-6) by Mycobacterium tuberculosis is associated with lower innate immune responses to infection. Here we show that ESAT-6 inhibited activation of transcription factor NF-kappaB and interferon-regulatory factors (IRFs) after Toll-like receptor (TLR) signaling; inhibition of TLR signaling by ESAT-6 required the kinase Akt."
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