Tuberculosis
New findings from Kyoto University, Medical Department in the area of tuberculosis described
Published in TB and Outbreaks Week, August 28th, 2007
"In order to know how caspases contribute to the intracellular fate of Mycobacterium tuberculosis and host cell death in the infected macrophages, we examined the effect of benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoro-methane (z-VAD-fmk), a broad-spectrum caspase inhibitor, on the growth of M. tuberculosis H37Rv in RAW 264 cells. In the cells treated with z-VAD-fmk, activation of caspase-8, caspase-3/7, and caspase-9 was clearly suppressed, and DNA fragmentation of the infected cells was also reduced," scientists in Kyoto, Japan report.
"Under this experimental condition, it was found that the treatment markedly inhibited bacterial growth inside macrophages. The infected...
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