Plague Therapy
Research data from United States Army Medical Research Institute of Infectious Disease update understanding of plague therapy
Published in TB and Outbreaks Week, September 18th, 2007
Fresh data on plague are presented in the report "Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague." According to a study from the United States, "Intentional release of Yersinia pestis will likely be propagated by aerosol exposure. We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy."
"Female BALB/c mice were exposed to 20 LD(50) of Y. pestis CO92 by aerosol. Treatments were saline (negative control), levofloxacin at 15 mg/kg every 12 h (positive control), doxycycline at 40 mg/kg every 6 h, and gentamicin at 12...
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