Tuberculosis
New tuberculosis study findings have been reported from M. Aleman et al
Published in TB and Outbreaks Week, September 18th, 2007
According to a study from Buenos Aires, Argentina, "Polymorphonuclear neutrophils (PNIN) modulate the adaptive immune response through interactions with immature dendritic cells (iDC) while spontaneous apoptotic neutrophils (PMNapo) may have an inhibitory effect on DC functions. We investigate the effect exerted by PMNapo in DC maturation and the role of Mycobacterium tuberculosis (Mtb)-induced PMNapo in the cross-presentation of mycobacterial antigens."
"We demonstrate that Mtb triggers the maturation of iDC while it is impaired by the presence of PMNapo, which abrogate Mtb-induced expression of costimulatory and HLA class II molecules, reducing IL-12 and IFN-gamma...
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