Tuberculosis
New tuberculosis research from Oregon Health & Science University outlined
Published in TB and Outbreaks Week, September 25th, 2007
Scientists discuss in "Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis" new findings in tuberculosis. "DevS is the sensor of the DevS-DevR two-component regulatory system of Mycobacterium tuberculosis. This system is thought to be responsible for initiating entrance of this bacterium into the nonreplicating persistent state in response to NO and anaerobiosis," scientists in the United States report.
"DevS is modular in nature and consists of two N-terminal GAF domains and C-terminal histidine kinase and ATPase domains. The first GAF domain (GAF A) binds heme, and this cofactor is thought to be responsible...
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