Tuberculosis Immunology
New tuberculosis immunology study results from J.M. Hougardy et al described
Published in TB and Outbreaks Week, September 25th, 2007
New research, "Regulatory T cells depress immune responses to protective antigens in active tuberculosis," is the subject of a report. According to a study from Brussels, Belgium, "Tuberculosis (TB) remains a leading cause of death, and the role of T-cell responses to control Mycobacterium tuberculosis infections is well recognized. Patients with latent TB infection develop strong IFN-gamma responses to the protective antigen heparin-binding hemagglutinin (HBHA), whereas patients with active TB do not. We investigated the mechanism of this difference and evaluated the possible involvement of regulatory T (Treg) cells and/or cytokines in the low HBHA T-cell responses of patients with...
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