Tuberculosis
International Medical Center, Department of Infectious Diseases reports research in tuberculosis
Published in TB and Outbreaks Week, October 23rd, 2007
A report, 'Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant mycobacterium tuberculosis strains,' is newly published data in Journal of Clinical Microbiology. "'Resistance of Mycobacterium tuberculosis to pyrazinamide (PZA) derives mainly from mutations in the pncA gene. We developed a reverse hybridization-based line probe assay with oligonucleotide probes designed to detect mutations in pncA," researchers in Shinjuku, Japan report.
"The detection of PZA resistance was evaluated in 258 clinical isolates of M. tuberculosis. The sensitivity and specificity of PZA resistance obtained...
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