Tuberculosis

Reports summarize tuberculosis study results from Fourth Military Medical University

Published in TB and Outbreaks Week, November 6th, 2007

According to a study from Xian, People's Republic of China, "Background Tuberculosis remains the leading cause of human death. Currently, Bacillus Calmette-Guerin (BCG) is the only available vaccine against tuberculosis but its efficacy is highly variable."

"Thus, developing new tuberculosis vaccines becomes an urgent task. In this study, we evaluated in BALB/c mice the humoral and cellular immune responses of recombinant BCG expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Escherichia coli-BCG shuttle plasmid named pDE22-esat-6 was constructed by inserting the BamHl/EcoRl digested esat-6 gene PCR product into the similarly digested parental plasmid pDE22....

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Source: TB and Outbreaks Week (2007-11-06)

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