Published in TB and Outbreaks Week, November 6th, 2007
"Thus, developing new tuberculosis vaccines becomes an urgent task. In this study, we evaluated in BALB/c mice the humoral and cellular immune responses of recombinant BCG expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Escherichia coli-BCG shuttle plasmid named pDE22-esat-6 was constructed by inserting the BamHl/EcoRl digested esat-6 gene PCR product into the similarly digested parental plasmid pDE22....
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