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Tuberculosis

Scientists at Harvard University target tuberculosis

Published in TB and Outbreaks Week, December 11th, 2007

New research, 'A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis,' is the subject of a report. "Many cases of active tuberculosis are thought to result from the reactivation of dormant Mycobacterium tuberculosis from a prior infection, yet remarkably little is known about the mechanism by which these non-sporulating bacteria reactivate. A family of extracellular bacterial proteins, known as resuscitation-promoting factors (Rpfs), has previously been shown to stimulate growth of dormant mycobacteria," scientists in the United States report.

"While Rpf proteins are clearly peptidoglycan glycosidases, the mechanism and role of Rpf in...

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