TB & Outbreaks Week
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Smallpox
Reports from Molsoft LLC add new data to research in smallpox
March 11th, 2008
"Essential for viral replication and highly conserved among poxviridae, the vaccinia virus I7L ubiquitin-like proteinase (ULP) is an attractive target for development of smallpox antiviral drugs. At the same time, the I7L proteinase exemplifies several interesting challenges from the rational drug design perspective," investigators in the United States report. "In the absence of a published I7L X-ray structure, we have built a detailed 3D model of the I7L ligand binding site (S2-S2' pocket) based on exceptionally high structural conservation of this site in proteases of the ULP family. The accuracy and limitations of this model were assessed through comparative analysis...
Source: TB & Outbreaks Week (2008-03-11)
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