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Drugs
Investigators at University Federal of Minas Gerais have published new data on drugs
March 11th, 2008
Research findings, 'Enhanced oral delivery of antimony from meglumine antimoniate/beta-cyclodextrin nanoassemblies,' are discussed in a new report. "The composition comprising the highly water-soluble drug meglumine antimoniate (MA) and beta-cyclodextrin (beta-CD) was shown previously to enhance the absorption of Sb by oral route and render MA orally active in a murine model of cutaneous leishmaniasis. This unexpected behaviour was attributed, in part, to the fact that the heating of equimolar mixture of MA and beta-CD (first step of preparation of MA/beta-CD composition) induced the depolymerization of MA from high-molecular weight Sb complexes into 1:1 Sb-meglumine complex, resulting in...
Source: TB & Outbreaks Week (2008-03-11)
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