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Enzyme Research
Research on enzyme research reported by scientists at Indian Institute of Science
March 11th, 2008
Investigators publish new data in the report 'Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.' According to recent research from Bangalore, India, "Glutamate racemase (MurI) catalyzes the interconversion of l-glutamate to d-glutamate, one of the essential amino acids present in the peptidoglycan. In addition to this essential enzymatic function, MurI from Escherichia coli, Bacillus subtilis and Mycobacterium tuberculosis inhibit DNA gyrase activity." "A single gene for murI found in the Mycobacterium smegmatis genome was cloned and overexpressed in a homologous expression system to obtain a highly soluble enzyme. In addition to...
Source: TB & Outbreaks Week (2008-03-11)
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