TB & Outbreaks Week
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Tuberculosis
Data on tuberculosis published by researchers at University of California
March 18th, 2008
According to recent research from the United States, "[GRAPHICS] Sulfolipid-I (SL-I) is an abundant metabolite found in the cell wall of Mycobacterium tuberculosis that is comprised of a trehalose 2-sulfate core modified with four fatty acyl substituents. The correlation of its abundance with the virulence of clinical isolates suggests a role for SL-I in pathogenesis, although its biological functions remain unknown." "Here we describe the synthesis of a SL-I analogue bearing unnatural lipid substituents. A key feature of the synthesis was application of an intramolecular aglycon delivery reaction to join two differentially protected glucose monomers, one prepared with...
Source: TB & Outbreaks Week (2008-03-18)
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