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Tuberculosis
Data on tuberculosis reported by researchers at Stanford University, Medical Department
March 18th, 2008
"Although a defective Th1 response has been demonstrated in patients infected with Mycobacterium tuberculosis (Mtb), the mechanisms leading to this defect are not well understood. To study the immune response to Mtb infection, we stimulated PBMC from individuals with latent tuberculosis infection (LTBI) or patients with tuberculosis (TB) with the Mtb specific antigen early secretory antigenic target-6 (ESAT-6). mRNAs for a panel of cytokines were measured using quantitative real-time PCR (qPCR)," scientists in the United States report. "PBMC from TB patients exhibited low levels of IFN-gamma, IL-12 alpha, IL-12 beta, and IL-23 mRNA but high levels of IL-9 mRNA. Sera...
Source: TB & Outbreaks Week (2008-03-18)
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