TB & Outbreaks Week
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Tuberculosis
Research from T. Shrivastava and co-authors in the area of tuberculosis published
March 25th, 2008
According to a study from Lucknow, India, "Rv3291c gene from Mycobacterium tuberculosis codes for a transcriptional regulator belonging to the (leucine responsive regulatory protein/regulator of asparigine synthase C gene product) Lrp/AsnC-family. We have identified a novel effector-binding site from crystal structures of the apo protein, complexes with a variety of amino acid effectors, X-ray based ligand screening and qualitative fluorescence spectroscopy experiments." "The new effector site is in addition to the structural characterization of another distinct site in the protein conserved in the related AsnC-family of regulators. The structures reveal that the...
Source: TB & Outbreaks Week (2008-03-25)
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