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Tuberculosis
Studies from K. Cotes and co-researchers in the area of tuberculosis published
March 25th, 2008
According to recent research from Marseille, France, "The Rv0183 gene of the Mycobacterium tuberculosis H37Rv strain, which has been implicated as a lysophospholipase, was cloned and expressed in Escherichia coli. The purified Rv0183 protein did not show any activity when lysophospholipid substrates were used, but preferentially hydrolysed monoacylglycerol substrates with a specific activity of 290 units center dot mg(-1) at 37 degrees C. Rv0183 hydrolyses both long chain di- and triacylglycerols, as determined using the monomolecular film technique, although the turnover was lower than with MAG (monoacylglycerol)." "The enzyme shows an optimum activity at pH values...
Source: TB & Outbreaks Week (2008-03-25)
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