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TB & Outbreaks Week

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Aspergillosis



Data on aspergillosis discussed by researchers at University of Minho



April 1st, 2008

According to recent research from Braga, Portugal, "Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis."

"A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46;P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization," wrote A. Carvalho and...


Source: TB & Outbreaks Week (2008-04-01)

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