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Enzyme Research
Recent findings in enzyme research described by researchers from University of Oxford
April 1st, 2008
According to a study from Oxford, the United Kingdom, "Arylamine N-acetyltransferase (NAT) enzymes are widespread in nature. They serve to acetylate xenobiotics and/or endogenous substrates using acetyl coenzyme A (CoA) as a cofactor." "Conservation of the architecture of the NAT enzyme family from mammals to bacteria has been demonstrated by a series of prokaryotic NAT structures together with the recently here the cloning, purification, reported structure of human NAT1. We report kinetic characterisation and crystallographic structure determination of NAT from Mycobacterium marinum, a close relative of the pathogenic Mycobacterium tuberculosis. We have also determined...
Source: TB & Outbreaks Week (2008-04-01)
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