TB & Outbreaks Week
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Tuberculosis
New tuberculosis research has been reported by scientists at University of Auckland
April 1st, 2008
According to recent research published in the journal Protein Expression and Purification, "A major obstacle associated with recombinant protein over-expression in Escherichia coli is the production of insoluble inclusion bodies, a problem particularly pronounced with Mycobacterium tuberculosis proteins. One strategy to overcome the formation of inclusion bodies is to use an expression host that is more closely related to the organism from which the proteins are derived." "Here we describe methods for efficiently identifying M. tuberculosis proteins that express in soluble form in Mycobacterium smegmatis. We have adapted the M. smegmatis expression vector...
Source: TB & Outbreaks Week (2008-04-01)
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