TB & Outbreaks Week
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Clinical Infectious Diseases
Data from W.A. Walker et al provide new insights into clinical infectious diseases
April 1st, 2008
"At birth, the newborn leaves the germ-free intrauterine environment and enters a highly contaminated extrauterine world, which requires potent host defenses to prevent disease. Intestinal defenses develop during gestation and have the capacity to respond but first must be exposed to colonizing bacteria," researchers in the United States report. "I review the importance of bacterial colonization for the appearance of normal mucosal immune function and the clinical consequences of inadequate colonization with regard to development of disease. For example, we now know that an imbalance in T-helper (Th) cells (e.g., Th2 levels greater than Th1 levels) can predispose to...
Source: TB & Outbreaks Week (2008-04-01)
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