TB & Outbreaks Week
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HIV/AIDS Co-Infection
Study data from Royal Liverpool University update understanding of HIV/AIDS co-infection
April 8th, 2008
According to a study from Liverpool, the United Kingdom, "In the developing world, early mortality within 1 month of commencing tuberculosis (TB) treatment is high, particularly with human immunodeficiency virus (HIV) co-infection. In Malawi, 40% of those who die do so in the first month of treatment." "Reasons remain unclear and may include delayed diagnosis, opportunistic infections, immune restoration inflammatory syndrome (IRIS) or malnutrition. One possible contributing factor is underlying hypoadrenalism associated with TB-HIV, exacerbated by rifampicin (RMP) induction of P450 and glucocorticoid metabolism. To assess the prevalence of hypoadrenalism in TB patients...
Source: TB & Outbreaks Week (2008-04-08)
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