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Legionnaire Disease
Investigators at Tufts University, Medical Department zero in on legionnaire disease
April 8th, 2008
"The function of phosphatidylcholine (PC) in the bacterial cell envelope remains cryptic. We show here that productive interaction of the respiratory pathogen Legionella pneumophila with host cells requires bacterial PC," scientists writing in the journal Cellular Microbiology report. "Synthesis of the lipid in L. pneumophila was shown to occur via either phospholipid N-methyltransferase (PmtA) or phosphatidylcholine synthase (PcsA), but the latter pathway was demonstrated to be of predominant importance. Loss of PC from the cell envelope caused lowered yields of L. pneumophila within macrophages as well as loss of high multiplicity cytotoxicity, while mutants...
Source: TB & Outbreaks Week (2008-04-08)
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