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Tuberculosis
Data from McGill University provide new insights into tuberculosis
April 8th, 2008
"The differential susceptibility of inbred mouse strains DBA/2J (susceptible) and C57BL/6J (resistant) to pulmonary tuberculosis following aerosol infection is under complex genetic control. In this report, transcriptional profiling with RNAs from Mycobacterium tuberculosis-infected lungs was used to investigate the physiological response, cell type, and biochemical pathways underlying differential susceptibility to infection," researchers in Montreal, Canada report. "Statistical analysis of cDNA-based microarrays revealed that 1,097 transcripts showed statistically significant changes in abundance (changes of >= 1.5-fold) in at least one of four experimental group...
Source: TB & Outbreaks Week (2008-04-08)
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