TB & Outbreaks Week
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Tuberculosis
Reports on tuberculosis findings from St. James Hospital provide new insights
April 8th, 2008
"Human macrophages infected with Mycobacterium tuberculosis may undergo apoptosis. Macrophage apoptosis contributes to the innate immune response against M. tuberculosis by containing and limiting the growth of mycobacteria and also by depriving the bacillus of its niche cell," researchers in Dublin, Ireland report. "Apoptosis of infected macrophages is well documented; however, bystander apoptosis of uninfected macrophages has not been described in the setting of M. tuberculosis. We observed that uninfected human macrophages underwent significant bystander apoptosis 48 and 96 h after they came into contact with macrophages infected with avirulent M. tuberculosis. The...
Source: TB & Outbreaks Week (2008-04-08)
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