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Tuberculosis
Studies from University of Montpellier update current data on tuberculosis
April 8th, 2008
According to recent research published in the journal Infection and Immunity, "PE and PPE proteins appear to be important for virulence and immunopathogenicity in mycobacteria, yet the functions of the PE/PPE domains remain an enigma. To decipher the role of these domains, we have characterized the triacylglycerol (TAG) hydrolase LipY from Mycobacterium tuberculosis, which is the only known PE protein expressing an enzymatic activity." "The overproduction of LipY in mycobacteria resulted in a significant reduction in the pool of TAGs, consistent with the lipase activity of this enzyme. Unexpectedly, this reduction was more pronounced in mycobacteria...
Source: TB & Outbreaks Week (2008-04-08)
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