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Tuberculosis
Study results from N. Ganguly et al provide new insights into tuberculosis
April 8th, 2008
"Mycobacterium tuberculosis (Mtb) causes death of 2-3 million people annually and is considered one of the most successful intracellular pathogens to persist inside the host macrophage. Recent studies have implicated the role of RD-1 region of Mtb genome in the mycobacterial pathogenesis," scientists in New Delhi, India report. "The role of RD-1-encoded secretory proteins of Mtb in modulation of macrophage function has not been investigated in detail. Here we show that RD-1 encoded two major secretory proteins, namely, culture filtrate protein-10 kDa (CFP-10) and early secreted antigenic target-6 kDa (ESAT-6), and their 1:1 CFP-10: ESAT6 complex inhibit production of...
Source: TB & Outbreaks Week (2008-04-08)
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