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West Nile Virus
New west nile virus study findings reported from B.L. Fredericksen and co-authors
April 8th, 2008
According to recent research published in the Journal of Virology, "RIG-I and MDA5, two related pathogen recognition receptors (PRRs), are known to be required for sensing various RNA viruses. Here we investigated the roles that RIG-I and MDA5 play in eliciting the antiviral response to West Nile virus (WNV)." "Functional genomics analysis of WNV-infected fibroblasts from wild-type mice and RIG-I null mice revealed that the normal antiviral response to this virus occurs in two distinct waves. The initial response to WNV resulted in the expression of interferon (IFN) regulatory factor 3 target genes and IFN-stimulated genes, including several subtypes of alpha...
Source: TB & Outbreaks Week (2008-04-08)
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