DNA Research

Research data from D. Vanquyen and colleagues update understanding of DNA research

Published in TB and Outbreaks Week, April 8th, 2008

"The E3L gene is essential for pathogenesis in vaccinia virus. The E3L gene product consists of an N-terminal Z alpha domain and a C-terminal double-stranded RNA (dsRNA) binding domain; the left-handed Z-DNA-binding activity of the Z alpha domain of E3L is required for viral pathogenicity in mice," scientists in South Korea report.

"E3L is highly conserved among poxviruses, including the smallpox virus, and it is likely that the orthologous Z alpha domains play similar roles. To better understand the biological function of E3L proteins, we have investigated the Z-DNA-binding behavior of five representative Z alpha domains from poxviruses. Using surface plasmon resonance...

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Source: TB and Outbreaks Week (2008-04-08)

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