Filovirus

Study findings on filovirus are outlined in reports from USA Scientific

Published in TB and Outbreaks Week, April 8th, 2008

According to recent research from the United States, "The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model."

"Previously, a uniformly lethal EBOV-Zaire mouse-adapted virus was developed by performing 9 sequential passages in progressively older mice (suckling to adult). Evaluation of this model identified many similarities between infection in mice and nonhuman primates, including viral tropism for antigen-presenting cells, high viral titers in the spleen and liver, and an equivalent mean time to death....

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Source: TB and Outbreaks Week (2008-04-08)

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