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Meningitis
Data on meningitis reported by A. Stucki and co-researchers
April 15th, 2008
Researchers in Bern, Switzerland conducted a study "To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin-resistant and a penicillin- and quinolone-resistant mutant." "EDP-420 was also tested against both strains in time-killing assays over 8 h in vitro. In experimental meningitis, EDP-420 produced a bactericidal activity comparable to the standard regimen based on a combination of vancomycin with ceftriaxone against a penicillin-resistant Streptococcus pneumoniae and a penicillin- and...
Source: TB & Outbreaks Week (2008-04-15)
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