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Tuberculosis
Research from Johns Hopkins University, Medical Department has provided new information about tuberculosis
April 15th, 2008
"To characterize the roles of SigB and SigF in sigma factor regulation in Mycobacterium tuberculosis, we used chemically inducible recombinant strains to conditionally overexpress sigB and sigF. Using whole genomic microarray analysis and quantitative reverse transcription-PCR, we investigated the resulting global transcriptional changes after sigB induction, and we specifically tested the relative expression of other sigma factor genes after knock-in expression of sigB and sigF," investigators in the United States report. "Overexpression of sigB resulted in significant upregulation of genes encoding several early culture filtrate antigens (ESAT-6-like proteins),...
Source: TB & Outbreaks Week (2008-04-15)
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