TB & Outbreaks Week
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Tuberculosis
Research in the area of tuberculosis reported from Emory University, Emory Vaccine Center
April 15th, 2008
According to recent research from the United States, "Tuberculosis remains a major global health problem that kills up to 2 million people annually. Central to the success of Mycobacterium tuberculosis (Mtb) as a pathogen is its ability to evade host immunity and to establish a chronic infection." "Although its primary intracellular niche is within macrophages, the underlying molecular mechanisms are poorly understood. Here we show that Rv2224c, a cell envelope-associated predicted protease, is critical for Mtb virulence. Disruption of Rv2224c led to prolonged survival of infected mice and highly reduced lung pathology. Absence of Rv2224c enhanced host innate immune...
Source: TB & Outbreaks Week (2008-04-15)
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