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Emerging Infectious Diseases

Research data from M. Barlow and colleagues update understanding of emerging infectious diseases

Published in TB and Outbreaks Week, April 22nd, 2008

According to recent research published in the journal Emerging Infectious Diseases, "We constructed a phylogenetic analysis of class A beta-lactamases and found that the bla (CTX-M)s have been mobilized to plasmids approximate to 10 times more frequently than other class A beta-lactamases."

"We also found that the bla(CTX-M)s are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted," wrote M. Barlow and colleagues.

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